Гепатитный минидайджест
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30.10.2013
Изложение на русском языке: "Обнаружен «мужской» вариант гепатита В" | ABC | http://www.abc-gid.ru/news/show/3969/
Абстракт по исследованию: Hepatitis B virus (HBV) mutation leading to gender disparity in the progression of liver diseases has not been explored so far. We aimed to elucidate relationships of the novel preS1 mutation, W4P/R with the progression of liver diseases and male predominance from a Korean chronic cohort through a molecular epidemiologic study. We developed a fluorescence resonance energy transfer (FRET)-based real-time PCR (RT-PCR) assay for detection of W4P/R mutation and applied it to 292 chronic patients. The preS1 mutations from a total of 247 patients (84.6%) of 292 were detected by this assay. W4P/R mutants were significantly related to severe liver diseases [HCC and liver cirrhosis (12.4%, 19/153 patients) vs. chronic hepatitis and carrier (1.1%, 1/94 patients), P < 0.001]. All of the W4P/R mutants were found only in the male gender, not in the female gender. The novel HBV preS1 mutation, W4P/R, may be associated with disease severity in male chronic patients infected with genotype C. The W4P/R mutation may in part provide the likely explanation for the relatively high ratio of male to female incidence in HCC generation in Korean chronic patients.
(http://jcm.asm.org/content/early/2013/09/06/JCM.01505-13.abstract)
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Новое лекарство от гепатита C дает серьезный побочный эффект |
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