Вкусная АРВ-терапия для детей
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05.12.2019
Источник: «Создана новая лекарственная форма препарата, облегчающая антиретровирусную терапию у детей» | https://medstrana.com/news/8337/ |
Индийская фармацевтическая компания Cipla разработала технологию производства комбинированного препарата в гранулах для терапии ВИЧ-инфекции у младенцев и детей. Такая лекарственная форма значительно облегчит прием жизненно необходимого лекарства маленькими пациентами.
В состав препарата в гранулах «Квадримьюн» (Quadrimune) входят 4 эффективных лекарства для антиретровирусной терапии: ритонавир, лопинавир, абакавир и ламивудин.
Прием ВИЧ-инфицированными детьми существующих лекарственных форм это препарата (таблетки, сироп с неприятным вкусом, содержащий к тому же этиловый спирт) значительно затруднен. Пациенты детского возраста часто выплевывают таблетки и сироп, что лишает их лечения, снижающего уровень вирусной нагрузки.
Теперь эта проблема решена, благодаря созданию специалистами компании Cipla новой лекарственной формы препарата в виде мелких гранул, обладающих клубничным вкусом. Такие гранулы можно добавлять в молоко/молочные смеси, прикорм детей первого года жизни и в обычную пищу и напитки для детей старшего возраста.
Кроме этого, «Квадримьюн» можно хранить при комнатной температуре, что крайне важно, принимая во внимание тот факт, что большинство детей с врожденной ВИЧ-инфекцией появляется на свет в странах Африки.
Компания Cipla уже подала заявку на регистрацию препарата «Квадримьюн» в Управление по контролю качества пищевых продуктов и лекарственных препаратов США.
Клинические исследования эффективности и безопасности этого лекарственного средства проводятся сейчас в Уганде совместно с исследовательским подразделением организации «Врачи без границ».
В настоящее время ежегодно рождается 160 000 детей, инфицированных вирусом иммунодефицита человека от матерей еще в период внутриутробного развития. Кроме того, каждый год около 80 000 детей (в основном младшего возраста) умирают от СПИДа.
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Source: «HIV treatment for children to be produced for under one dollar a day» | https://www.dndi.org/2019/media-centre/press-releases/hiv-treatment-for-children-to-be-produced-for-under-one-dollar-a-day/ |
The Indian pharmaceutical company Cipla has announced their commitment to price the ground-breaking new product Quadrimune, a “4‑in‑1” treatment for young children with HIV, at below a dollar a day. Quadrimune is currently under review by the US Food and Drug Administration (FDA) for use in children between 3 and 25 kg bodyweight.
This pleasant tasting, heat-stable fixed-dose combination of four antiretrovirals (ARVs) for infants and young children with HIV was developed in partnership by Cipla and the not-for-profit Drugs for Neglected Diseases initiative (DNDi) with financial support from Unitaid and other donors. If it receives FDA tentative approval in 2020, the 4-in-1 will represent a major improvement in the treatment of HIV in very young children and will replace older, bitter-tasting medicines, medicines requiring refrigeration, or regimens that are no longer recommended by the World Health Organization (WHO).
‘Cipla is happy that over the past 20 years it has contributed to making adult antiretroviral drugs available at affordable prices for patients throughout the developing world, in particular Africa, and has pioneered the development of paediatric fixed-dose combinations of ARVs for children,’ said Dr Yusuf K Hamied, Chairman of Cipla. ‘Over the years, the treatment of children with HIV has been neglected. In order to ensure faster access, particularly in sub-Saharan Africa, our product Quadrimune, once approved, will be offered for less than one dollar a day for children.’
‘Children living with HIV have been neglected for too long, with the recommended treatment for years consisting of a bitter-tasting syrup with 40% alcohol content,’ said Dr Bernard Pécoul, Executive Director of DNDi. ‘Mothers were often forced to bury the syrup in the sand to keep it cool, because it required refrigeration. The new Quadrimune is pleasant-tasting, heat-stable, and easy-to-use. We will finally have a treatment designed specifically for infants and young children, who are at the highest risk of dying if they do not receive treatment.’
It is estimated that 1.8 million children are living with HIV, almost 90% of whom live in sub-Saharan Africa. Only an estimated 54% of these children have access to HIV treatment and over 300 children still die from the disease every day. Inappropriate, suboptimal treatment options have contributed to low treatment coverage.
4-in-1 being administered on a spoon with food
Demonstration of how to administer Quadrimune, a “4-in-1” treatment for young children with HIV
Quadrimune contains the WHO-recommended ARVs abacavir, lamivudine, lopinavir, and ritonavir in the form of granule-filled capsules. If approved, parents and caretakers will be able to administer the drugs to children by sprinkling the granules on soft food, water, or milk. The 4-in-1 does not require refrigeration and is easy to administer to infants and children of different weights and ages.
Cipla will provide Quadrimune at an ex-factory price of US$ 15 per pack of 120 capsules, giving a price of $1 per day ($360 per year) for children in the medium weight bracket of 10 to 13.9 kg, with prices lower, at 50 US cents per day, for younger children and infants.
‘This optimal child-adapted all-in-one ARV regimen, that meets WHO recommendations, will be a game-changer for millions of infants and young children,’ Unitaid Executive Director Lelio Marmora said. ‘Unitaid is proud to have supported from day one the development of this new 4-in-1 treatment that is safe and effective, adapted and palatable, easy-to-use and with no requirement for refrigeration. Once adopted, this innovative formulation will enable great advances in the treatment of the youngest kids.’
Since 2013, WHO has recommended regimens that include a class of ARVs called protease inhibitors, which includes lopinavir/ritonavir (LPV/r), for infants and young children. Cipla and DNDi worked closely to develop Quadrimune, testing over 30 formulations of abacavir, lamivudine, and LPV/r, ensuring good taste-masking, and selecting one which met the standards required to enable regulatory submission.
The 4-in-1 could be the first of several new treatment options now on the horizon for young children with HIV.
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